The Colorado Buffaloes (1-2) and the Wyoming Cowboys (2-1) play at Folsom Field on Saturday, September 20, 2025.
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Colorado vs. Wyoming Matchup Info
- Game date: Saturday, September 20, 2025
- Game time: 10:15 p.m. ET
- Location: Boulder, Colorado
- Venue: Folsom Field
- TV channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Colorado vs. Wyoming Odds and Prediction
- Spread favorite: Buffaloes (-11.5)
- Moneyline: Buffaloes (-465), Cowboys (+354)
- Total: 45.5 points
- Pick ATS: Colorado (-11.5)
- Pick OU: Under (45.5)
- Prediction: Colorado 24, Wyoming 11
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Colorado vs. Wyoming Betting Records and Insights
- Colorado has covered once in three games with a spread this season.
- Wyoming has won two games against the spread this season.
- The Buffaloes have been favored by 11.5 points or more once this season, and covered the spread.
- The Cowboys have not covered the spread this season (0-1 ATS) when playing as at least 11.5-point underdogs.
- Games featuring Colorado have gone over the point total once this season.
- Wyoming and its opponent have not yet hit the over in 2025.